After what happened in the last episode, Zoey is worried that Mark might find out her secret. On the day of the Kendo tournament that Mark is in, Dren attacks Mark with an Amoeba Predasite. Will Zoey be brave enough to defeat Dren's Predasite and keep Mark from getting killed?
- Because The Main Mew's Muse was not considered an actual episode, there is a significant plot hole caused by the "disappearance".
- The episode title is a pun on the phrase "Time and time again"
- As the episode 12 "The Main Mew's Muse" was made into episode 1 in the English dub Mew Mew Power, the reason that Zoey is worried about is different to Ichigo.
- Instead of being spotted by the tree, the previous episode is where the Mews are shown on live TV and that makes Zoey worried.